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[39] [40] Many e-liquids use nicotine salts made by adding organic acids such as benzoic acid to nicotine, so as to reduce throat irritation

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On page 15 of the patent, Pax said it had unexpectedly discovered the efficient transfer of nicotine to the lungs of an individual and a rapid rise of nicotine absorption in the [blood] plasma. The companys patent used graphics to show that its effects surpassed that of Pall Mall a popular Reynolds cigarette as users blood nicotine levels spiked dramatically, then fell by almost half within 15 minutes

Additional analyses of data from both tasks that did not include the physiological noise modelling regressors produced a highly similar set of results (see Supplementary Figure 3), suggesting that physiological effects are not a significant confound in the data

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