Pharmacokinetic interactions are primarily due to substances in tobacco smoke, such as hydrocarbons or tar-like products that cause induction (speeding up) of some liver enzymes (CYP 1A2, in particular)
Sci Rep 8:1829 Centers for Disease Control and Prevention (2018) Behavioral and Clinical Characteristics of Persons with Diagnosed HIV InfectionMedical Monitoring Project, United States, 2010 Cycle to 2015 Cycle
This is important as our population gets older because aging and smoking are both risk factors for dementia." The findings, published in Biological Psychiatry: Global Open Science, were a result of comparing 32,094 smokers' smoking history, brain imaging, genetic predisposition and other health data points
But having a variety would be fantastic
Not as much ingredients to try picking out so now I can actually taste the different tobaccos and now understand the descriptions other people have used