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muciniphila was found to reverse the low-grade chronic inflammatory state in HFD mice to a certain extent, including a significant increase in the gene expression of inflammatory and immunosuppressive factor interleukin (IL)-10, as well as a decrease in the mRNA levels of tumor necrosis factor- (TNF-), Monocyte chemoattractant protein-1, and Toll-like receptor 2 (TLR2) (Yang et al., 2020)

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To evaluate reversibility, TGR inhibitors were tested in the jump dilution assay 46,47

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J Alzheimers Dis , 2020, 74(2): 615-624

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