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3.2 Indications: The approved indications for SGLT2 inhibitors include: Diabetes mellitus Heart failure Chronic kidney disease 3.3 Benefits and Harms of Continuation/Discontinuation in the Perioperative Period: 3.3.1 Benefits: Improved Glycemic Control: Continued use may help maintain stable blood glucose levels

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Altogether, circulating GLP-1 can affect central signaling by complementary pathways, thereby supporting satiety-related signaling

So it keeps the chondrocyte, which is the cell that preserves cartilage and minimizes the progression of arthritis, and therefore makes its function better. Bert Mandelbaum, MD

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