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generic Nicotine is well absorbed across the skin Delivery to systemic circulation avoids hepatic first-pass metabolism Plasma nicotine levels are lower and fluctuate less than with smoking TRANSDERMAL NICOTINE PATCH:DIRECTIONS for USE Choose an area of skin on the upper body or upper outer part of the arm Make sure skin is clean, dry, hairless, and not irritated Apply patch to different area each day Do not use same area again for at least 1 week TRANSDERMAL NICOTINE PATCH:DIRECTIONS for USE(contd) Remove patch from protective pouch Peel off half of the backing from patch TRANSDERMAL NICOTINE PATCH:DIRECTIONS for USE(contd) Apply adhesive side of patch to skin Peel off remaining protective covering Press firmly with palm of hand for 10 seconds Make sure patch sticks well to skin, especially around edges TRANSDERMAL NICOTINE PATCH:DIRECTIONS for USE(contd) Wash hands: Nicotine on hands can get into eyes or nose and cause stinging or redness Do not leave patch on skin for more than 24 hoursdoing so may lead to skin irritation Adhesive remaining on skin may be removed with rubbing alcohol or acetone Dispose of used patch by folding it onto itself, completely covering adhesive area TRANSDERMAL NICOTINE PATCH:ADDITIONAL PATIENT EDUCATION Water will not harm the nicotine patch if it is applied correctly

[186] They have to be pre-registered to the Medicines and Healthcare products Regulatory Agency before sale

BMC Med Inform Decis Mak 21(Suppl 6):206

Augusta, Georgia May 1962 Photographer- John Dominis Time Inc Owned Merlin- 1143150 (The LIFE Picture Collection via )Date taken: 5/1962: Los Angeles Angels pitcher Bo Belinsky sitting in dugout during game

Some automatic pre roll machines do more than just create the pre roll