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A variety of chemicals present in cigarette smoke enhances transepidermal water loss, upregulation of matrix metalloproteases (MMP) MMP-1 and MMP-3 implicated in collagen and elastic fibers degradation which, together with induced oxidative stress, contribute to the degeneration of connective tissue and premature aging in the skin [61]

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How weed affects you can really depend on stuff like how often you use it, how you're using it (smoking, edibles, etc.), and what your own health situation is like