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Nicotine and coronary blood flow Nicotine can decrease coronary blood flow by acting on vascular smooth muscle 1-adrenergic receptors to constrict coronary arteries, but can also increase coronary blood flow by increasing cardiac output, causing subsequent flow-mediated dilation (FMD), and directly stimulating coronary artery 2-receptor for coronary vasodilation

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So she was earning millions and dominating the operatic stages, yet she remained bound to patriarchal laws