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Once inhaled, reactive electrophiles, such as flavorings commonly used in e-liquids, activate TRPA1 by covalent modification of cysteine residues, altering protein complex conformation and facilitating inward flow of cations [116118]

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The 26 physical examinations, including blood and lung function tests, were completed by all participants in strict accordance with the Physical Examination Standards for Civil Servants of China 16

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