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Severe gastrointestinal adverse effects (persistent vomiting or diarrhoea) can lead to dehydration and, in susceptible individuals, acute kidney injury

For each included study, data was extracted on study design, baseline population characteristics, intervention details (type and dose of GLP-1 receptor agonists), comparator, mean follow-up duration and reported cardiovascular outcomes

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Aside from GHS-R1a, hexarelin can also bind to the scavenger receptor CD36