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Antioxidant effects after coffee enema or oral coffee consumption in healthy Thai male volunteers S Teekachunhatean N Tosri C Sangdee R Wongpoomchai W Ruangyuttikarn C Puaninta S Srichairatanakool We designed an open-label, randomized two-phase crossover study to investigate the antioxidant effects after single and multiple doses of a coffee enema versus coffee consumed orally

10.1038/s41467-024-54635-x 135 MillerP

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Commonly observed adverse effects include abdominal discomfort, bloating, flatulence, and diarrhea, which generally diminish as the hosts system acclimates to the microbial intervention (552)