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Phase 2 results at 48 weeks (Jastreboff et al., NEJM 2023): Phase 3 TRIUMPH-4 at 68 weeks (Lilly Press Release, Dec 2025): The 12 mg dose produced 28.7% body weight loss, an average of 71.2 lbs from a 248.5 lb baseline

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Novel combination therapy with hepsin and low doses of NAC improves therapeutic effectiveness and extends survival in APAP-induced lethality The standard clinical approach for treating APAP-induced liver injury involves administering NAC

170 , 178 In those individuals with GS deficiency and oxoprolinemia, administration of oral sodium bicarbonate or citrate is necessary to control acidosis

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