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Cigarette smoke impairs endothelial function due to vagal input from the airway rather than a specific smoke constituent The ability of blood vessels to widen was examined in the rat study before and after exposure to smoke from four types of classic combustible cigarettes: conventional nicotine, reduced nicotine, conventional nicotine with added menthol, and reduced nicotine with added menthol

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Only four HPHCs tested were measurable in nicotine pouches, and the pouch products tested showed no presence of nitrosamines or polycyclic aromatic hydrocarbons

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A standard pack of Marlboro Red Japan typically contains 20 cigarettes