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Abbreviations B.P.: Blood pressure NA: Network analysis BA: Betulinic acid DA: Dihydrogathic acid HQ: Hydroquinidine TPC: Total phenolic content TFC: Total flavonoid content GAE/g: Gallic acid equivalent per gram SYR: Syringaresinol DPPH: 2,2-Diphenyl-1-picrylhydrayl ABTS: 2,2-Azino-bis-3-ethylbenzothia-zoline-6-sulphonic acid GI: Gastrointestinal AE: Aqueous extract ME: Methanolic extract DNA: Deoxyribonucleic acid H 2 O 2 : Hydrogen peroxide XXO: Xanthine oxidase STZ: Streptozocin LDL: Low density lipoprotein HDL: High density lipoprotein SOD: Superoxide dismutase CAT: Catalase GR: Glutathione reductase MAPK: Mitogen-activated protein kinase ROS: Reactive oxygen species NF- B: Nuclear factor kappa B Bcl-2: B-cell lymphoma 2 Bax: Bcl-2 Associated X-protein Bcl-XL: B-cell lymphoma-extra large ADAM: A Disintegrin and metalloproteinase HeLa: Henrietta lacks HAEC: Human aortic endothelial cells TNF-: Tumour necrosis factor References Adhimoolam K, Sureshbabu A, Smirnova E et al (2024) -Sitosteroldietary sources and role in cancer and diabetes management

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Conversely, the combined gastrointestinal effects may prove intolerable for some patients, with compounded nausea, diarrhoea, or constipation limiting the feasibility of concurrent use