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38 In a nationwide cohort study of 120,054 patients with type 2 diabetes with a median follow up of 7.4 years, there was an 11% reduction in the rate of dementia when GLP-1 receptor agonists were used as a second-line treatment compared with other glucose-lowering therapies and the risk reduced with increasing duration of GLP-1 receptor agonist exposure (liraglutide in 95% of patients)

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It leaves the choice of formulation to the provider, who it says should weigh medical history, renal function, cardiovascular history, and medication interactions before deciding

They speculated that the amount of insulin that does not induce A deposition may induce the limited expression of insulin receptors on the hippocampal neurons under pathological conditions (Kamei et al., 2018)