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15,37,39-41 To be effective, legislative measures to reduce access need to: 38,42 be regularly enforced, in order to ensure high compliance rates involve a penalty that is not so low that it will not act as a deterrent, but not so high that it is not supported by community attitudes be uniform so that minors cannot avoid them by shopping elsewhere

46,5658 This type of effect is seen in the CCL2-CCR2 signaling pathway between BC cell and TAMs that promote the initial recruitment of inflammatory macrophages to the premetastatic niche, where these macrophages evolve into metastasis-associated macrophages (MAMs)

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