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Notably, young adults misusing tramadol showed increased rates of seizures, while older adults on long-term anticholinergic therapy demonstrated significant cognitive decline, reinforcing age and misuse as critical modifiers of risk

Comparing the cluster models results to the separate molecule models results, it can be seen that the energetics are comparable, the final product P2 of the separate molecule model and the final product P2a of the cluster model are close in energy, see the energy profile of the cysteine oxidation in Fig

Trends Endocrinol Metab 31(11):85971 Kongsuphol P, Mukda S, Nopparat C, Villarroel A, Govitrapong P (2009) Melatonin attenuates methamphetamine-induced deactivation of the mammalian target of rapamycin signaling to induce autophagy in SK-N-SH cells

[DOI] [PMC free article] [PubMed] [Google Scholar] 183.Morones J.R., Elechiguerra J.L., Camacho A., Holt K., Kouri J.B., Ramrez J.T., Yacaman M.J