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This controversial response could be associated with the presence of estrogens, as it was reported that bombesin inhibits GH secretion in normal rats but exerts stimulatory role in estrogenized rats (246)

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Secondly, while the ZSF1 obese rat recapitulates key features of cardiometabolic HFpEF, including diastolic dysfunction, hypertrophy, and metabolic comorbidities, no animal model perfectly mirrors the complex and heterogeneous pathophysiology of human HFpEF

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