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Clinical trials suggest tirzepatide (Mounjaro/Zepbound) produces greater average weight loss than semaglutide (Ozempic/Wegovy)

These findings suggested that once approved as a pharmaceutical agent, the Si-based agent could be highly expected to help alleviate the symptoms of UC because the range of efficacy of the Si-based agent was very wide

All GCT enzymes possess a highly conserved pocket, proposed to be the active site, which contains a catalytically relevant glutamate residue

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In January 2025 it became the first GLP-1 receptor agonist approved to reduce the risk of worsening kidney disease and cardiovascular death in adults with type 2 diabetes and chronic kidney disease, based on the FLOW trial