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The islets are micro organs consisting of about a couple of hundred to a couple of thousand endocrine cells, including the beta cells, alpha cells, delta cells, pancreatic polypeptide cells and epsilon cells

ER/ER ratio and aromatase expression levels as well as 2-hydroxyestrone:16-hydroxyestrone ratios are becoming used as biomarkers to direct phytoestrogen or DIM (diindolylmethane) supplementation, whereas the NF-B, STAT3 and PI3K/Akt phosphorylation status potentially indicating curcumin, resveratrol or polyphenols use for chemosensitizing