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Despite substantial progress, a long road lies ahead to end the tobacco epidemic through the effective and innovative implementation of tobacco-control policies.

J Dev Phys Disabil 15 , 335349, doi:10.1023/A:1026310216069 (2003)

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Pathogenesis Imbalance between mucosal defensive factors and aggressive factors Defensive Factors Prevent the stomach and duodenum from being harmed (self-digestion)