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Plausible biologic mechanisms by which smoking might be protective in COVID-19 include an anti-inflammatory effect of nicotine, a blunted immune response in smokers (reducing the risk of a cytokine storm in COVID-19) and increased nitric oxide in the respiratory tract (which may inhibit replication of SARS-CoV-2 and its entry into cells)
Focusing on the iteractions between parasites and their hosts, with fungi and cyanobacteria as models, Erika Martinez-Ruiz discovered that compounds leached from cigarette butts, including metals and nicotine , can inhibit infection by chytrid fungi
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