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Continuous GH exposure (as with some therapeutic approaches) can lead to receptor downregulation and diminished tissue responsiveness

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In addition, patients with major depressive disorder may suffer from either increases or decreases in appetite and weight during a depressive episode (Milaneschi et al., 2019), which is associated with differences in energy metabolism (Simmons et al., 2018) and function of the reward circuit (Kroemer et al., 2022

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