Here is the honest state of the data: Obesity (Phase 2, randomized controlled trial): the landmark New England Journal of Medicine Phase 2 trial in obesity established both the once-weekly dosing and the escalation approach, and reported the largest average weight reductions seen for a once-weekly agent with the caveat that the reduction had not fully plateaued at 48 weeks
Enzyme-sensitive nanocarriers have been engineered for targeted drug delivery in tumors and cancer cells, facilitating prodrug activation, morphological modification, and physical disruption
Missing injections or stopping treatment because of side effects may interrupt progress and contribute to disappointing results
Li, T., Fu, F., Wu, C., Qin, F
doi: 10.3389/fnagi.2024.1363115 64