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The standard dosing schedule builds up slowly for this reason, and some providers use even more gradual approaches for patients who are particularly sensitive

Research has shown that weekly injections at higher doses may promote fracture healing to a similar extent as daily lower-dose injections in rodent models, though human verification of weekly protocols is still in progress

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After discussion, the study director must then approve the protocol by affixing their dated signature

First, cytoskeletal remodeling supports neurite outgrowth and neuronal survival , and T4 has been shown to promote these by upregulating the cell-adhesion molecule L1