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Co-expression of ACE2 with membrane serine proteases is high on ileal absorptive enterocytes in the GI tract, nasal goblet secretory cells and type II pneumocytes in the respiratory tract, as well as on the urogenital epithelia 59,60

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Thats because when the body sees an overload of unstable molecules and the body could no longer scavenge the amount, their accumulation generates oxidative stress that could lead to the development of various issues

doi: 10.1016/j.jconrel.2020.10.059, 84

it results in $147 billion in health care spending annually (204)