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The mammalian target of rapamycin complex 1 (mTORC1) stimulates the oxidative branch of the PPP by enhancing the sterol regulatory element-binding protein (SREBP)-dependent transcription of G6PD (65, 66)

The resulting iron ions then circulate in the plasma as Fe 3+ , binding with transferrin (Tf) to form iron-transferrin complexes ( 3+ from Tf, which is then reduced to Fe 2+ by prostate six transmembrane epithelial antigen 3 (STEAP3) ( The gut exhibits precise regulation of iron homeostasis

Eating foods high in iron, folate, and vitamin B12 may help increase platelets

ER-phagy and ERAD also collaborate to maintain proAVP maturation and to protect AVP neurons against proteotoxicity, thereby leading to an increase in AVP neuron survival

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