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A risk haplotype of STAT4 for systemic lupus erythematosus is over-expressed, correlates with anti-dsDNA and shows additive effects with two risk alleles of IRF5

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This weakened barrier permits bacteria and bacterial products, such as lipopolysaccharide (LPS), to translocate across the intestinal wall and enter the bloodstream, contributing to systemic inflammation and sepsis (Ghosh et al., 2020)

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