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In his later images, Closes constellation of portrait subjects continued to expand to include celebrities such as Kate Moss and Willem Dafoe, and prominent political figures including Presidents Bill Clinton and Barack Obama

It's a reference to the movie "This Is Spinal Tap", where that picture is from

To go along with the nicotine, tobacco smoke contains several substances known as monoamine oxidase (MAO) inhibitors which interfere with the MAO's enzymes responsible for breaking down the "feel good" neurotransmitters

The chemicals in tobacco can interfere with the natural development of vital organs, which can have lasting effects on the childs health

Benzene: Another carcinogen found in cigarette smoke, which is also present in gasoline and industrial emissions