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Factors Contributing to Glutathione Depletion: Factors such as chronic stress, poor diet, environmental toxins, and certain medical conditions can deplete glutathione levels, increasing the importance of monitoring and maintaining optimal levels

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78 However, the demonstration of endothelial dysfunction in the presence of increased expression of eNOS indicates that the capacity of the enzyme to produce NO may be limited, and the concept that eNOS itself can be a superoxide source and thereby contributes to endothelial dysfunction provides a further explanation to this observation