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The body synthesizes carnitine endogenously in the liver, kidneys, and brain

Alpha-tocopherol is believed to be the first part of an antioxidant network (shown below) where it is oxidized to donate an electron to stabilize reactive oxygen species

Vegetarians and vegans consume much less dietary carnitine, but healthy adults still synthesize carnitine

The article describes soluble fiber from sources such as oats or psyllium as working with hydration to add stool bulk and hold water in the colon, and says insoluble fiber from wheat bran and vegetables should be introduced cautiously since excess may initially increase discomfort

Cardiomyocytes from Hsp27 overexpressing mice also had altered histology and ultrastructure with evidence for increased cardiomyocyte diameter and protein aggregation