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In the review of 22nd Century Group, Inc.'s MRTP applications, the FDA evaluated data from both the company and FDA testing and found that nicotine levels in tobacco and mainstream smoke of VLN cigarettes are at least 96% lower than the majority of marketed and market-leading conventional cigarette brands

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As a result, smoking has contributed significantly to the disparity in the rates of mortality between those with lower levels and those with higher levels of educational attainment (Wong et al

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