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Our study results in mice were not meant to be compared to human disease, but instead argue that e-cigarette smoke must be more thoroughly studied before it is deemed safe or marketed that way. Nicotine and Nitrosamines The question of whether nicotine itself, separate from tobacco smoke, causes cancer is controversial because of conflicting study results over time that used oft-criticized methods

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Exclusion criteria included trials marked as "completed," "terminated," "unknown," or "withdrawn."

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