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Despite suggestions from both the scientific community and government agencies that nicotine may cause cardiometabolic harm long-term [18, 20], we know of no previously published trials that prospectively reported on beneficial cardiometabolic effects when quitting regular snus use

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For example, changes in the abundances of several genera of the child microbiome of the finger, nose, mouth, and ear canal have been reported after exposure to third-hand smoke

This occurs because the brain's receptors become less responsive to nicotine, requiring higher doses to produce the same dopamine release