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[32] Viral replication, in turn, increases cellular levels of cytokines, like tumor necrosis factor-alpha (TNFa), that promote the production of free radicals and the activation of NFkB, initiating a vicious cycle of viral replication and free radical production

The cost difference makes treatment accessible to people who otherwise couldnt afford brand-name prices

After the February 2025 shortage resolution and April 22, 2025 enforcement deadline, each prescription requires prescriber evaluation and documented clinical rationale not just shortage status reasoning

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however, they are no longer commonly used in clinical medicine