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A conclusion of a recent National Academy of Science Report on e-cigarettes read e-cigarettes cannot be simply categorized as either beneficial or harmful to health. And a recent review in the British Medical Journal of the respiratory effects of e-cigarettes noted they have measurable adverse biologic effects on organ and cellular health in humans

Tobacco product use among Adults - United States, 2021

You dont need to understand the chemistry to choose correctly - just know that higher strengths are generally more comfortable in nicotine salts, while lower strengths work well with freebase nicotine

Vol 100 E, 377504 (2012)

By then, it was too late for Bogart