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A 1990 New England Journal of Medicine Letter to the Editor describes a 21-year-old nonsmoking asthmatic female who developed wheezing within 10 min of using toothpaste containing mint or wintergreen flavoring [93]

Heat exposure and drugs

Early versions were unwieldy, delivered an inadequate "hit" of nicotine and suffered from what was unkindly described as a "hernia effect" users had to suck hard to get anything at all

Though there is some harm associated with nicotine the real harm comes from burning tobacco, and it is this which should be reduced to create a real reduction in harm

[24] Possessing, using or buying vapes carries a maximum fine of $2,000