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All trials had a parallel-group design and 15 were open-label (Table 1)

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doi: 10.3389/fphar.2021.748193 Received 27 July 2021 Accepted 20 September 2021 Published 04 October 2021 Volume 12 - 2021 Edited by Jian Gao, Shanghai Childrens Medical Center, China Reviewed by Zhongling Zhang, First Affiliated Hospital of Harbin Medical University, China Chunxue Wang, Beijing Tiantan Hospital, China Updates Copyright 2021 Xue, Zhang, Xing, Liu, Zhang, Wang and Yu

Surgery is typically the first treatment option for localized MMNST, aiming to remove the tumor with clear margins