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However, the enzyme DPP-4 rapidly degrades circulating GLP-1, limiting its duration of action

This directly complicates patient screening and enrollment, leads to substantially lower overall expected efficacy compared with patients harboring upstream genetic defects (such as POMC deficiency) [56] , and results in a low statistical success rate in large-scale trials

Anti-sympathetic drugs, such as -blockers, may represent suitable candidates in combination with DPP-4 for the treatment of hypertension with which to prevent sympathetic activity

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Clinical Associate Professor of Plastic Surgery at Texas Tech University Health Sciences Center, teaching the same techniques I use every week