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All tirzepatide doses were more efficacious than GLP-1 RAs in achieving a body weight loss of at least 10% and 15% (ESM Table 2)

The generalized type tends to be symmetric, whereas the localized form, which can follow a mosaic distribution, is more common in children and more difficult to treat [62, 63]

Central nervous system-mediated appetite regulation represents a primary mechanism through which GLP-1 RAs induce weight reduction and subsequently improve hepatic steatosis

Circulation, 146(24), 18821894

Your body has an energy budgetit needs a certain amount of calories from food to maintain daily functionality, plus pay for any and all physical activity