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Harvested tracheal grafts were fixed in 4% paraformaldehyde, embedded in paraffin, sectioned at 5 m, and stained with Hematoxylin and Eosin (H&E) for general histology, and Toluidine Blue for cartilage analysis

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In some cases, they couldn't find any published clinical studies in humans and there were safety concerns like the potential to encourage cancer growth or to trigger a massive immune response