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Our study highlights the importance of characterizing the e-cigarette nicotine delivery profile before conducting a randomized controlled trial

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(Regular cigarettes might feature one ring of ventilation holes, while light and ultra-light cigarettes of the same brand might have two or more rings.) These tiny holes, which you can see by holding the unrolled paper up to a bright light, can allow enough fresh air into the smoke that such cigarettes can test quite low in tar and nicotine levels when smoked by machines, which do not cover the holes