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Among them, gene K01115 (KEGG) encoding phospholipase DLD) 1/2, which was found to participate in both carcinogenesis and inflammation/oxidative stress response pathways (Supplementary file Figures 11 and 12), was significantly enriched in both type II CRC [FDR adjusted p=0.016, Log 2 (FC)=1.68] and type II adenoma [FDR adjusted p=0.01, Log 2 (FC)=1.65] subgroups (Supplementary file Figure 13)

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Tobacco is grown on 1.5 percent of the countrys total cultivated area