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It causes the blood vessels to secrete substances that are pro-inflammatory and encourage clots
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In a prespecified time-to-benefit secondary analysis presented at the European Congress on Obesity in 2025 and subsequently published, semaglutide produced a nominally significant reduction in MACE within the first 3 months (HR 0.63, 95% CI 0.410.95) and the first 6 months (HR 0.60, 95% CI 0.440.81), with curve separation visible within approximately 3 weeks of randomization [25], [26]