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The structural change ( Figure 7E ) could potentially hinder the transamination reaction, because the loop movement might bring the -amino group of PMP into closer proximity to other amino-acid side groups, such as His192, promoting the hydrogen bond formation that may influence the reactivity of PMP with GSA

These side effects include cataracts, steroid-induced diabetes, and bone problems such as osteoporosis and avascular necrosis (AVN), a condition in which the bone dies due to inadequate blood supply

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Think of them as fertilizer for your probiotic garden