So I'll give you an example the grapefruit diet
"Tar Director Todd Field Helped Invent Big League Chew"
John Schoenherr's cover for the July 1965 cover of Analog magazine includes a chill raccoon smoking through a cigarette holder while sitting on the knee of a dinosaur who's arguing with a guy in a jumpsuit about which direction to go on an alien planet
The usage examples (10 units/day for each method) illustrate comparable nicotine intake
Mast cells release vasoactive and angiogenic compounds and proinflammatory mediators, such as arachidonic acid metabolites (prostaglandin D 2 , leukotrienes), histamine, cytokines (e.g., IL-6 and IFN) and chemokines (e.g., eotaxin, MCP-1, and RANTES), platelet-activating factor (PAF), heparin, and proteolytic enzymes (21)