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Firstly, -glucans, as a key component, have been shown to activate the secretion of -defensin, IL-6, and IL-10 in sheep rumen explants, thereby promoting mucosal immunity and enhancing the local immune defense against pathogens [101]

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Clinical Evidence Human Trials: A randomized, placebo-controlled study in obese adults demonstrated that AOD-9604 significantly reduced abdominal and total body fat over several weeks of treatment, without serious side effects Animal Studies: Preclinical studies in mice and rats showed that AOD-9604: Stimulated lipolysis Inhibited lipogenesis (formation of new fat) Prevented weight gain despite high-fat diets This dual actionenhancing fat breakdown and inhibiting fat formationpositions AOD-9604 as a potent tool for combating obesity

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The study indicates that the process is due to the transdifferentiation between islet cells, and the intestine-islet GLP-1/GLP-1R/PKA signal pathway is one of the important pathways to produce this process ( GLP-1 is one of the hormones responsible for the incretin effect, and exerts a wide variety of actions such as potentiation of glucose-stimulated insulin secretion, reduction of appetite, delay of gastric emptying and inhibit cell dysfunction ( PC1/3 and PC2, as the important proteases of cell, play an important role in the process of transforming proinsulin into insulin ( In order to have a further study about the effect of berberine on GLP-1/GLP-1R/PKA signaling pathway, we performed experiment in vitro

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