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40 Urgent or emergency surgery may be required when severe colitis is refractory to medication and the individual is increasingly unwell, develops TM, or develops a bowel perforation or a major hemorrhage

This is particularly important for medications that rely on a stable concentration in the bloodstream, such as antiepileptic drugs or some antihypertensives

Focusing on well-studied examples of NDDs allows us to consider the broader implications of our conclusions for NDDs as a whole

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