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Smoking has the following effects

I think this is the primary reason it has gone unnoticed by tobacco control researchers, institutions, media, etc." But that is changing

Of all the included studies, only seven evaluated the effects of electronic cigarettes in a healthy non-tobacco smoking population, these studies revealed significant effects, including increases in heart rate, mean arterial blood pressure, arterial stiffness, and oxidative stress, as well as respiratory system changes such as alterations in the transcriptomes of the respiratory epithelium and alveolar macrophages, and a sudden increase in airflow resistance suggesting airway obstruction

Yeah, exactly

En 1880, il est vendu cent millions de cigarettes dans le monde, en 1900 un milliard de cigarettes [38]