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Daily smokers and nondaily smokers had about twice the odds of relapsing to drug use at the end of the three-year period compared to nonsmokers

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Characterization of the adverse effects of nicotine on placental development: in vivo and in vitro studies

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Studies have shown that administration of nicotine in rats causes an increase in Basal layer collagen fibers, destruction of Sertoli cell intercellular connections, chromosomal abnormalities, degenerative germ cells, excessive accumulation of fat droplets in the sperm cytoplasm, and morphological abnormalities in the sperm [37]