doi: 10.2337/dc09-1959 70 GersteinCHColhounMHDagenaisRGDiazRLakshmananMPaisPet al
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Critically, a positive feedback loop emerges between accumulated long-chain acylcarnitines and excessive ROS: these acylcarnitines inhibit electron transport chain complex III, inducing ROS overproduction, whereas ROS suppresses CPT2 activity, preventing further metabolism of long-chain acylcarnitines [55, 135,136,137,138]
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These findings suggest that oxidative stress is intimately linked to a variety of pathophysiological processes, such as inflammation, oligodendrocyte abnormalities, mitochondrial dysfunction, hypoactive N -methyl-D-aspartate receptors and the impairment of fast-spiking gamma-aminobutyric acid interneurons.[bkyb1] Such self-sustaining mechanisms may progressively worsen producing the functional and structural consequences associated with schizophrenia